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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0a49bef72dee673726b1d6df1b397eb8893af2ef5bd86a2bb07f0f27aa3149f0' 
  AND token = 'U0HFBHzphAI91iVyf+GZQpm2kgz06v0MXGqwmyuTf44=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00031

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}