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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2c81d618c9f569de271a96b35bdaf20b0ca72e630be3301cb37ec3d1a7bf0111' 
  AND token = '+Iu8DRmfrhWIu1yjS+e+EwFcT+RCYfUhBXNWhAWSOA0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00046

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}