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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '53f78f759a1c0f6914df93c5125c010da613ede876019251a1f9a85065196273' 
  AND token = 'ZL/kWhfKxoz9DEua20CMkBhS+WNXPyYEMMAWRLmXDgM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}