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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0b0a5388f1c9d66a4d443485283c02c6c39a16fb91dfd685c54d26e8bd218222' 
  AND token = 'cyX5busR1Sx3k3c0In63kiUbwznyrt1dW1PC2v+qaWQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}