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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '300ca607a687bd9cc7af8865d188dcfca88fc0d3f119b9251fec8d9d8e861a15' 
  AND token = 'FM25Mcu57a+fT1n5Ah/DPjRo40BM7dYe3njCz04OsGQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}