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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '490eeadbfff3e065776468ef541df4e96efb97bd57da2eb49c51196368030550' 
  AND token = '80My/U9005kj+SPldK6qn3oCUCrHzYwxgptvE7AYsD0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00045

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}