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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7e681c9cb40eb9435ffd1f1e98f0717b5a5b3e07b2e5781247793a5a8b70e909' 
  AND token = 'HyK19+4xHWoOEjMjF4SVhrvEBSDXHtsCa1FQzQzAjHA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00037

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}