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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5c5e41c1868c5d59dab021c6ed7deb0c6374933292a08ee8a155c1785f2f25ef' 
  AND token = 'tKGTUbv39Ey0zoacTkk0Cv7Mm00OG+4qBbbEXAn7o6A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}