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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '10df3a6e003f17ad9d33d08eec8df63e5f1b75ec8169768061b390259959c8b5' 
  AND token = 'qVSupk4UxVWUqSr3y9fyCzaOW21Ajc61IYsxSl97GsI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00014

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}