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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '426c2be0fd8349e063519e29399a76d4f8d4e99290d1d99f480154bc9884c9ed' 
  AND token = 'G+8XsrSc1EoRVGWQBACTD3d7/cL0vAoXhv/hRV2fJSo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}