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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '105b497a12df7cac7948932b24cb8dfc1aaf20f792eaf3eabdb61519d96dfc3c' 
  AND token = 'JG7yrHdmv+feFG9BMFqfa2uuQDFbTg1sx3Cl5vk9XTw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}