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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '589fb0965a05ed5e64ade557ecf5425111de7ff9a68b7e7894e8a26e5c81f830' 
  AND token = 'HcuzIgep0ahjt9r5TJzGHVkkPCSwBw4L0FiIEHHQRDc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}