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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '495f3009a1631bee7bc69badd5f9b02d4e12c88c0c11688c1e2f7aca5a166df0' 
  AND token = 'P0zvkE/H067x/brBhYlEZva9QQJ4QY8dZ2gvpaijQ40=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}