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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2af9ae0200c73f59d138e524cf726342d9de4dc6146b3cc5ecbad0f5fad1bd75' 
  AND token = 'qVqlH++dALxtWdOIOPbAULpDV3VqTvtro07AtJWM3ck=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}