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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0d351621e31e89a7d26fefe77a8f0c2312b139003d2365f3782f1fd2e35cd494' 
  AND token = 'EdKY04n+gVcMe5fZ+iWO0cdhBSUX2IDOxoHt2AdrzGU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}