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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ed3bbad46bc51c8ac9d9d7e1b45a13fab203d205b2354773cc915333aed63f60' 
  AND token = 'ITO2JO1GuP70lMCEgw9Z1W1Cjh0gFLdGpVLsnsG2CVg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}