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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '53dcb2f2b1302faf88826332684622793c3b0d0d630c139c0bac1bb8ce956510' 
  AND token = 'Ps0gOoMUem/u+J0hPBzs9mNl9np9qDJ8PsD5KnPkzZQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}