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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '19e78a7ff36e3e943586ffa3fe499a20587ecafee4edf9f776eaa3ba0bde107c' 
  AND token = 'jxpWM1SH+WR+5FTlmetDI9Q/jH412Zv2y3TCGXtQWIQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}