SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49fadbc0121c4ac22810e33fb89032bd0217814c00dff57e61cffb47670f06e6' 
  AND token = 'VkZK+mWTiiNCvW5CDP1p1+m1Q/iDSeqD6LzXoDFBKU8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}