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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'dc22da47b15077cbc38e35d3e541d0f6444be0ab341e4b1822c46d093e46b9dd' 
  AND token = 'yA0ZQTJ6O2/s2QJTvV9IUkULqGRNcN9QS46JfTZYK/g=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}