SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '43e35ec1f2f8396bf23a986f196bf234c723800944aa195444da67f83fe3b75f' 
  AND token = 'eWzSe6uDURP3hWNtX/MgDXL01iiQh5UQMXjHA6CxCH0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}