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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e0b8cbf8ab3b8908769a92ae16101b93b0c5c90fa58a81db96615d2431fade78' 
  AND token = 'HMfgkjFIZtDFOB1zyq+Vljj8x9akzwAA8kUvLpWb9X8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}