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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b28851fa36e26cf5b3459d7e5358cb38757de3cd4bfd7b283c652293a8b99acb' 
  AND token = 'itSDNnnNcuMxqzjrBra/Ik0UKetvZQP/ZAhfkmyNpxQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}